- Title
- Second-hand exposure of staff administering vaporised cannabinoid products to patients in a hospital setting
- Creator
- Solowij, Nadia; Galettis, Peter; Broyd, Samantha J.; de Krey, Peter; Martin, Jennifer H.
- Relation
- Drugs in R & D Vol. 18, Issue 1, p. 41-44
- Publisher Link
- http://dx.doi.org/10.1007/s40268-017-0225-5
- Publisher
- ADIS International
- Resource Type
- journal article
- Date
- 2018
- Description
- Background: In many health settings, administration of medicinal cannabis poses significant implementation barriers including drug storage and safety for administering staff and surrounding patients. Different modes of administration also provide different yet potentially significant issues. One route that has become of clinical interest owing to the rapid onset of action and patient control of the inhaled amount (via breath timing and depth) is that of vaporisation of cannabinoid products. Although requiring a registered therapeutic device for administration, this is a relatively safe method of intrapulmonary administration that may be particularly useful for patients with difficulty swallowing, and for those in whom higher concentrations of cannabinoids are needed quickly. A particular concern expressed to researchers undertaking clinical trials in the hospital is that other patients, nurses, and clinical or research staff may be exposed to second-hand vapours in the course of administering vaporised products to patients. Objective: The objective of this study was to take samples from two research staff involved in administering vaporised ∆⁹-tetrahydrocannabinol to participants in a clinical trial, to examine and quantitate cannabinoid presence. Methods: Blood samples from two research staff were taken during the exposure period for three participants (cannabis users) over the course of approximately 2.5 h and analysed using tandem mass spectrometry. Results: Blood samples taken over a vaporised period revealed exposure below the limit of detection for ∆⁹-tetrahydrocannabinol and two metabolites, using tandem mass spectrometry analytical methods. Conclusions: These results are reassuring for hospital and clinical trial practices with staff administering vaporised cannabinoid products, and helpful to ethics committees wishing to quantify risk.
- Subject
- medicinal cannabis; drug storage; drug safety; administration; health safety
- Identifier
- http://hdl.handle.net/1959.13/1401883
- Identifier
- uon:34976
- Identifier
- ISSN:1174-5886
- Rights
- This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2282
- Visitors: 3323
- Downloads: 1050
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 283 KB | Adobe Acrobat PDF | View Details Download |